• FK228 br Conflict of Interest Disclosures br

  2018-11-09

  

  Conflict of Interest Disclosures Author contributions Introduction Large for gestational age (LGA), defined as a birth weight≥90th percentile for gestational age, is the predominant adverse outcome associated with maternal hyperglycemia (Langer et al., 2005; Metzger et al., 2008). LGA is th

• Regarding JNK phosphorylation levels were either moderately

  2018-11-08

  

  Regarding JNK, phosphorylation levels were either moderately (for JNK 1) or significantly increased (for JNK 2/3) at 5μM SB203580 compared to DMSO controls; these effects were further pronounced at 30μM (Figs. 5 A–B, schema in Figs. 6 C–D). This suggests a concentration-dependent activation of JNK b

• While stem cell based therapies hold

  2018-11-08

  

  While stem cell-based therapies hold great potential for the treatment of a wide array of medical conditions they are so novel that product characterization is particularly challenging. Despite considerable progress, the molecular regulatory mechanisms of self-renewal and lineage specification in th

• Recently inherently tumor tropic stem cells

  2018-11-08

  

  Recently, inherently tumor-tropic stem cells have received a great deal of attention for their clinical potential to treat diverse human cancers. For example, hNSCs are reported to be very effective in delivering various therapeutic agents in preclinical models of malignant olda tumors including me

• Introduction Gene engineered hematopoietic stem

  2018-11-08

  

  Introduction Gene engineered hematopoietic stem and progenitor Aminoallyl-dCTP - Cy3 (HSPCs) are the basis of a promising therapeutic approach for a variety of diseases, including HIV/AIDS, Wiskott–Aldrich syndrome and metachromatic leukodystrophy (Cartier & Aubourg, 2010; Sheridan, 2011; Aiuti et

• br Materials and methods br Acknowledgments This

  2018-11-08

  

  Materials and methods Acknowledgments This work was supported by grants from the National Basic Research Program of China (973 program 2011CB964901 and 2012CB944901), the National Natural Science Foundation of China (81101510 and 31101053), Natural Science Foundation of Hunan Province (14JJ200

• br Material and methods br Acknowledgement We thank Jane Hag

  2018-11-08

  

  Material and methods Acknowledgement We thank Jane Hagelskjær Knudsen, Christian Knudsen, and Bettina Hansen for excellent technical assistance. This project was supported by Aarhus University and partially by the Lundbeck Foundation (R151-2013-14439) and Danish Council for Independent Researc

• br Results br Discussion The

  2018-11-08

  

  Results Discussion The availability of Lgr5 as a specific marker for stem cyclooxygenase pathway in the intestine and other tissues has allowed the unequivocal identification of intestinal stem cells, as well as molecular profiling (Muñoz et al., 2012), the establishment of culture methods (Sa

• Pathway analysis on these genes

  2018-11-08

  

  Pathway analysis on these genes identified their role in stem-cell-maintenance-related Wnt pathway (Baker, 2010), cell-cycle-related p53 pathway, JAK stat, and MAPK pathways in addition to others listed in Table S4. These results suggest a potential contribution of multiple signaling pathways for st

• Introduction Glioblastoma multiforme GBM is

  2018-11-08

  

  Introduction Glioblastoma multiforme (GBM) is the most common adult primary purchase ABT-199 tumor, with an extremely dismal prognosis and high rate of recurrence following standard therapy (Wen and Kesari, 2008). Populations of brain tumor initiating cells (BTICs), which express many of the proper

• br Results br Discussion In this

  2018-11-08

  

  Results Discussion In this study we provide several lines of evidence that Dnd serves as a critical PGC specifier in medaka. First, dnd knockdown is capable of specifically and completely abolishing PGC formation and its overexpression is sufficiently capable of inducing ectopic PGCs in embryo

• MYC is not a pluripotency factor

  2018-11-08

  

  MYC is not a pluripotency factor, but it substantially improves reprogramming dynamics, primarily because MYC accelerates cell proliferation (Sabo et al., 2014; Walz et al., 2014), providing an opportunity for the somatic genome to gradually reshape its epigenetic landscape. MYC is critical at an ea

• Below we highlight what has been preserved and what is

  2018-11-08

  

  Below, we highlight what has been preserved and what is new in the 2016 ISSCR Guidelines for Stem Cell Research and Clinical Translation. We also provide a window into our deliberations and describe key elements of the process from which these revised guidelines emerged. Specific recommendations emb

• br Results br Discussion The dataset allows a well

  2018-11-07

  

  Results Discussion The dataset allows a well-defined comparison of protein abundance and phosphorylation in pluripotent Linsitinib and the earliest definitive hNSCs. This contrasts with previous studies that used hESCs and heterogeneous mixtures of differentiated progeny (Brill et al., 2009;

• Evidence that these variables can be used as

  2018-11-07

  

  Evidence that these variables can be used as instruments is provided in Table 5, which demonstrates a correlation between the instruments and budget indices but not between the instruments and the primary deficit for the sample period. Thus, for each index and sub-index, equation (1) was re-estimate

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