• Several ongoing clinical trials are evaluating the feasibili

  2018-10-23

  

  Several ongoing clinical trials are evaluating the feasibility of combining chemotherapeutic nanomedicines with radiotherapy or small molecule drugs (such as gemcitabine). Pegylated liposomal doxorubicin has shown improved therapeutic efficacy when combined with radiotherapy in several animal studie

• Clinical randomised studies such as

  2018-10-23

  

  Clinical randomised studies such as the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complication have shown that early intensive glycemic control reduces risk, whereas prolonged hyperglycaemia can increase the long term risk of diabetic complications (

• Past contributions of military medicine to civilian health c

  2018-10-23

  

  Past contributions of military medicine to civilian health care are numerous and substantive. They include improvements in ground and aeromedical medical evacuation (Larrey, 1814; Connor, 2010), regulation (Anon., 1937), open treatment of severe wounds (Moorhead, 1942a, 1942b; Gould, 1917), the comb

• orthopox Children with CRS may be

  2018-10-23

  

  Children with CRS may be infectious for the entire first year of life, rarely even longer (Cooper and Krugman, 1967; Rawls et al., 1967), and can transmit the virus causing infection in non-immune individuals (Hardy et al., 1965; Greaves et al., 1982; Schiff and Dine, 1965). The infant mortality rat

• Three compelling sets of data from

  2018-10-23

  

  Three compelling sets of data from our studies suggest that, in combination with a Th1-skewed antibody response, CD4 T Digoxigenin-11-ddUTP correlate with VLP-mediated protection under a durable protection murine model. First, the frequency of IFNγ-producing T cells was significantly higher in the

• br Competing Interests br Author Contributions br

  2018-10-23

  

  Competing Interests Author Contributions Acknowledgments This review is supported by the Mitchell Center for Neurodegenerative Diseases and John Sealy Memorial Fund. We are grateful to the Kayed lab members for their helpful suggestions. Introduction Recent developments in cancer immuno

• Influenza proteins inside the viral envelope are highly

  2018-10-23

  

  Influenza proteins inside the viral envelope are highly conserved across different strains and subtypes of influenza. Two internal proteins that have been extensively studied in the context of influenza infection are nucleoprotein (NP) and matrix protein 1 (M1). NP binds and transports the RNA genom

• Most of our DSAs were de novo and their development

  2018-10-23

  

  Most of our DSAs were “de-novo”, and their development was predicted by donor and recipient ages. Other studies reported younger age at LT and medication non-compliance to be predisposing factors, which was not confirmed in our cohort (Del et al., 2014). Only three children developed both Class II D

• Conflicts of Interest br The paper by addresses important

  2018-10-23

  

  Conflicts of Interest The paper by addresses important issues in understanding the heterogeneous pathogenetic pathways in Wilms tumors and also practical questions of how sensitive and specific is a tumor biopsy for identifying important genetic changes. Histopathologists are used to morphologic

• The succesful development of flavivirus vaccines began years

  2018-10-23

  

  The succesful development of flavivirus vaccines began 80years ago in 1937 with the yellow fever YFV17D live-attenuated vaccine (Monath, 2008). Since then, >600 million people have been vaccinated, with 98% protection and a >10year persistence of vaccine–induced immunity (Barrett and Teuwen, 2009).

• Baseline levels of biomarkers of immune activation and infla

  2018-10-23

  

  Baseline levels of biomarkers of immune activation and wnt inhibitor were similar by treatment arm, and there were no differences between treatment groups at weeks 12, 24, or 48 (p>0.05, Supplementary Table 1) for any of the markers, except for IL-6 at week 12 only (median, TAF: 1.4pg per mL, TDF:

• Previous family based studies did not take into account

  2018-10-23

  

  Previous family-based studies did not take into account e but the overall evidence suggested that shared environment between twins did not contribute to MDD () in line with Zeng et al. that did not identify any effect of shared environment between siblings or family members. On the other hand, indiv

• Boyle and Beeson argue that a recent report by Sack

  2018-10-23

  

  Boyle and Beeson argue that a recent report by Sack et al. () using late arresting genetically attenuated parasites (LAGAP) supports the role of vasopressin receptor antagonist and complement in controlling parasitemia. In this study, the authors report that immunization with LAGAP induces antibodi

• Accumulating scientific evidence suggests different profiles

  2018-10-23

  

  Accumulating scientific evidence suggests different profiles of each IgG subclass in protection against pathogens. Human IgG1 is the most dominant subclass in human sera and generally plays an important role in the protection against a variety of viral infections. In addition to inactivation and/or

• Asymptomatic colonization of the nasopharynx almost invariab

  2018-10-23

  

  Asymptomatic colonization of the nasopharynx almost invariably precedes disease; however, pneumococci vary in their capacity to colonize the nasopharynx, both in humans and in animal models. Certain serotypes and/or clonal groups are more often isolated from carriers, while others are more often iso

15750 records 1047/1050 page Previous Next First page 上5页 10461047104810491050