• br O GlcNAc transferase OGT belongs to

  2021-03-15

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• ym express synthesis Potential break through technology pois

  2021-03-15

  

  Potential break-through technology poised to overcome these above-mentioned limitations is that of the “substrate mediated enzyme prodrug therapy”, SMEPT (Fig. 1). Learning from the previously established enzyme prodrug therapies (EPT) and specifically the antibody-directed EPT (ADEPT) [12], develop

• br Discussion The etiology of autoimmune diseases

  2021-03-15

  

  Discussion The etiology of autoimmune diseases including psoriasis is intricate and a composite of environmental and biological factors. There are very limited studies available that report the association analysis of ACE I/D polymorphism with psoriasis risk. In the current study we report on ass

• Studies using SERPINB deficient mice established the

  2021-03-15

  

  Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi

• DCA receptor br Material and methods br Results br Discussio

  2021-03-15

  

  Material and methods Results Discussion Isolated DCA receptor have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, the

• PCI-34051 br Inhibition of DHODH The final products

  2021-03-15

  

  Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct

• Expression of DDR in endothelial cells has been previously d

  2021-03-15

  

  Expression of DDR1 in endothelial cells has been previously described in human corneal blood vessels, and more recently, in murine atherosclerotic plaques (Franco et al., 2008, Mohan et al., 2001). So far, there is a lack of evidence for DDR1 expression in endothelial cells in the mouse pyridoxal ph

• The methods used for cytokine

  2021-03-15

  

  The methods used for cytokine analysis, such as ELISA or multiplex systems could also influence the concentrations of cytokines analysed. It is therefore crucial to use the same lot of the multiplex analysis kit to make such a comparison [21]. In our study, we ensured that the analysis was performed

• The sequence identity of CYP A

  2021-03-15

  

  The sequence identity of CYP3A163 with CYP3A sequences from other species is maximum in reptiles ranging (75-91)%, gradually decreasing from bafilomycin (63-71)% to mammals 62% to downwards based on evolutionary distances. The high level of homology with CYP3A77 in Alligator mississippiensis sugges

• Mitophagy is a selective autophagic process which

  2021-03-15

  

  Mitophagy is a selective autophagic process which leads to the degradation of damaged mitochondria in response to metabolic or environmental stress conditions. In this study, we found that LFS-01 treatment significantly enhances p62 in a time-dependent manner. We found that the upregulation of p62 i

• One specific brain region that may

  2021-03-15

  

  One specific SAG receptor region that may be involved in the reduction of anxiety after anti-SVG-30 treatment is the lateral septum which contains a high density of CRF2 receptors [5], [44]. The lateral septum often exhibits increased immediate early gene expression in response to stress and anxiet

• Cubic equations of state CEoS are particularly popular due

  2021-03-13

  

  Cubic equations of state (CEoS) are particularly popular due to their simplicity and relatively good accuracy in predicting vapour-liquid equilibrium and liquid-liquid equilibrium for small, non-polar, non-associating molecules, such as light hydrocarbons. CEoS can match the phase boundaries (L/LL a

• VAS2870 The classification of CK substrates based on

  2021-03-13

  

  The classification of CK2 substrates based on active enzyme subunit composition provides a framework for understanding the regulatory function of CK2β subunit. However, few experiments exist that functionally explore such classification [17], [18], [19], [20], [21], [22], [23]; this reflects practic

• Interestingly several ES cell lines are

  2021-03-13

  

  Interestingly, several ES cell lines are null for p53, possibly because the EWS-FLI1 chimeric protein can directly and indirectly interfere with p53 activity [38], [39]. The inhibition, loss and/or mutation of p53, one of the most common events in tumorigenesis, results in a decreased oxygen consump

• br Advent of SMEPT br SMEPT for localized synthesis

  2021-03-13

  

  Advent of SMEPT SMEPT for localized synthesis of nitric oxide Critical evaluation and outlook Examples discussed in this review present SMEPT as a methodology for localized drug synthesis – a unique opportunity for site specific therapeutic interventions using implantable biomaterials. This

15801 records 670/1054 page Previous Next First page 上5页 666667668669670 下5页 Last page