• Finally the effect of the BMIM

  2020-10-26

  

  Finally, the effect of the [BMIM][BF4] concentration change on the P-T diagram of methane hydrate was predicted using the proposed model. Three various concentrations (including 10%, 15% and 20%) were considered for calculations. The experimental data [49] and modeling results are demonstrated and c

• Unlike previous studies examining COMT genotyping

  2020-10-26

  

  Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT trpv was associated with differences in gambl

• br Materials and methods br Results Recently a quantitative

  2020-10-26

  

  Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis

• br Materials and methods br Results br

  2020-10-26

  

  Materials and methods Results Discussion Persimmon tannin has been reported to have the bile acid binding ability in vitro (Matsumoto et al., 2011) and hypolipidaemic effects in animals (Matsumoto et al, 2008, Zou et al, 2012). Our previous study also proved that persimmon tannin promoted t

• The attachment of ubiquitin to RTKs such as EGFR

  2020-10-26

  

  The attachment of ubiquitin to RTKs, such as EGFR, mediates efficient delivery through the endosome-lysosome system for proteolysis. In this way, RTK degradation enables cessation of signal transduction. A recent siRNA screen identified a number of USPs that can significantly modulate EGFR levels an

• L-Cysteinesulfinic acid In addition to cleaving ubiquitins

  2020-10-26

  

  In addition to cleaving ubiquitins off modified proteins, DUBs can also cleave between ubiquitin moieties within a polyubiquitin chain to edit the ubiquitin signal. DUBs employ different strategies to recognize polyubiquitin (Figure 1). DUBs that rely only on interactions on the S1 site tend to be L

• Additional derivatives were synthesised using a modified app

  2020-10-26

  

  Additional derivatives were synthesised using a modified approach (). Commercially available 4-bromo-2-methoxyaniline () was converted into the boronic ester , followed by a Suzuki–Miyaura cross-coupling with chromenone triflate to afford the corresponding arylamine . Acylation of with chloroacety

• Western blotting and flow cytometry was employed to

  2020-10-26

  

  Western blotting and flow cytometry was employed to assess the DNA-PK inhibition of LTU28 and LTU31 in combination with radiation. It has been previously reported that phosphorylation of DNA-PKcs at the Thr2609 cluster plays an important role in DSB repair and resistance to radiation (Ding et al., 2

• In this report we present spectroscopic

  2020-10-26

  

  In this report, we present spectroscopic evidence on the effect of different solvents having proton acceptor and proton donor ability and pH of the medium on the abstraction of amino proton of PI (Scheme 1) for controlling the nonradiative rates. Despite the general utility of PI as a DNA intercalat

• calcitonin receptor br Results br Discussion The sequence ho

  2020-10-26

  

  Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into calcitonin receptor by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the kinases by th

• br Materials and methods br Author

  2020-10-26

  

  Materials and methods Author contributions Acknowledgements Supported by grants from the Zhejiang Provincial Natural Science Foundation (LY16H030016, LY17H030012), and the Zhejiang Science and Technology Public Welfare Project (2015C33279), Anesthesiology Center in North of Zhejiang Provinc

• Instead of receptor interaction or GT

  2020-10-26

  

  Instead of receptor interaction or GT activity, we focused on the CPD and autoprocessing. The CPDs from the 2 toxins are highly homologous: each cysteine protease targets an intramolecular substrate and mediates InsP6-induced autoprocessing to release the GTD into host cytosol.40, 41 However, TcdB i

• It is well known that corticotropin

  2020-10-26

  

  It is well-known that corticotropin-releasing factor (CRF) exerts its biological functions through binding to type-1 (CRF1) and/or type-2 (CRF2) receptors. Several clinical evidences suggest the association of a high level of CRF and the onset of anxiety and depressive disorders.2, 3, 4, 5, 6, 7 Si

• Park et al expanded their

  2020-10-26

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino cimetidine tagamet solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausnitz

• In recent years neuroimaging studies

  2020-10-26

  

  In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on N-Methyl-D-aspartic acid function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions in activity d

16476 records 795/1099 page Previous Next First page 上5页 791792793794795 下5页 Last page