• Nicotine is the main psychoactive component

  2020-02-17

  

  Nicotine is the main psychoactive component of tobacco that causes addiction. Besides the regulation of the stress responses, CRF has been implicated in nicotine addiction based on several lines of evidence (Bruijnzeel and Gold, 2005, Sarnyai et al., 2001). First, acute administration of nicotine, l

• br Acknowledgements br A subgroup of pediatric solid neoplas

  2020-02-17

  

  Acknowledgements A subgroup of pediatric solid neoplasms, collectively referred to as small round cell tumors (SRCTs) of childhood, demonstrates undifferentiated small round cell morphological characteristics. The SRCTs include neuroblastomas, lymphomas, and several bone and soft tissue sarcoma

• The elastase induced injury model has been shown to

  2020-02-17

  

  The elastase-induced injury model has been shown to produce airspace enlargement, and increases in lung volume and compliance that are similar to those observed in human patients (Hantos et al., 2008, Hamakawa et al., 2011). Thus, this model, which has been used to study emphysema, should be adequat

• 3280 br Acknowledgements br Introduction Three

  2020-02-17

  

  Acknowledgements Introduction Three structurally related fungal metabolites have been isolated from chloroform extracts of submerged rice cultures of Aspergillus terreus 23-1 from stored unhulled rice in Taiwan; these were named territrems A–C to indicate their biological origin (A. terreus) a

• Our study found a significant association between

  2020-02-17

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P EGFR OPP australia status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR

• br Experimental Procedures br Author Contributions br Acknow

  2020-02-15

  

  Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s

• br Results and discussion br Conclusion Analogues of

  2020-02-14

  

  Results and discussion Conclusion Analogues of 1,2,4-triazole and 1,3,4-oxadiazole have been designed, synthesized and characterized. To avoid late stage failure, it is important to study the preliminary pharmacokinetic parameters. The results of pharmacokinetic data suggested that, all molecu

• We had earlier reported that collagen fibers

  2020-02-14

  

  We had earlier reported that collagen fibers with intact native banded structure were occasionally observed in the kinase-deficient, membrane-anchored DDR2 ECD (DDR2/-KD) samples; however, in our DDR1/ECD and DDR2/ECD samples, observation of native banded structure of collagen was far more infrequen

• T0070907 To elucidate the potential mechanism underlying ost

  2020-02-14

  

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine T0070907 and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were arrested in G1 phase of

• Recent studies investigating the effects

  2020-02-14

  

  Recent studies investigating the effects of mesenchymal stem cell (MSC) therapy in rodent models including chronic renal failure and glomerulonephritis have demonstrated that MSC therapy can result in beneficial effects [57], [58]. In cats, autologous intra-renal injections of either adipose tissue-

• Previous studies have shown the harmful effects of

  2020-02-14

  

  Previous studies have shown the harmful effects of NEFA on ovarian functionality, such as inhibition of bovine granulosa cell survival and proliferation, steroidogenesis, and follicular development and alteration in oocyte development [36,45,46]. Therefore, the higher levels of NEFA found in the fol

• br Introduction br Multiple levels of CK AKT

  2020-02-14

  

  Introduction Multiple levels of CK2/AKT cross-talk Isoform-specific signaling in CK2/AKT cross-talk Particularly relevant to the scope of this review, it has been shown that depletion of the CK2 catalytic α′ subunit is more effective than that of the α subunit at reducing AKT Ser129 phospho

• One of the hallmarks of the terminal stages

  2020-02-14

  

  One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa

• br Discussion Electroporation is a convenient and

  2020-02-14

  

  Discussion Electroporation is a convenient and efficient way to introduce foreign material into Alrestatin [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant to successful elect

• Introduction Human cytomegalovirus CMV is

  2020-02-13

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

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